Clerics, except for raise dead spells, require only one spell component - their holy symbol, this is the rule for all spells regardless of the description in the PHB or other sources. Clerics are utterly tied to their holy symbol, which is why most will have more than one in their possession. If they lose access to their holy symbol, they cannot cast any spells. One free feat clerics receive at first level is Create Holy Symbol. This requires 1 hour of prayer at an obelisk or holy site, (or six hours otherwise) and they must verbally say the required prayers. If they are unable to complete the verbal and somatic components, they cannot complete this ritual.
Wizards do not require spell components for spells less than 3rd level while in cities, as there is plenty of magical energies as a result of the obelisks or temples nearby. This is not assumed to be the case in remote areas. The dedication of the obelisk is unimportant, if it acts as a connection to the heavenly or demonic forces, it will still charge all spell casters as noted above.
Constructs treat their HD number as their intelligence, wisdom and charisma scores until they reach 15 HD. If they have an intelligent score higher than 7, they can speak. Otherwise use as per the construct entry in the MM. Constructs have no soul at creation, though rare, it is possible for them to generate one. Some sentient constructs worship the Holy Cog, and can gain cleric levels in lawful forces.
Cosmology There are no stars in the sky. 4 moons dominate. The seasons, magic cycles, predictions are based on their relative locations. There are actually more than 100 moons all around, very few of them are ever actually visible without a telescope, but they all have meaning and most have specific connections to magic, fate and the gods. Weeks are also usually called the Ten-Day. Years are called Cycles. Months are often called Turns, and are each five weeks long there are 15 to a standard year. Holidays occur outside of the weeks.
Deities The High Gods cannot physically come to Nyssa, only their proxies or servants. Most gods have multiple domains, each will have a different proxy or Avatar. These are utterly and completely loyal. Demi-Gods are able to walk the land, but only in areas of their faithful.
Active vs Passive Skill Checks: If the player asks to do something, that is an active roll, and done as normal. At any time, a DM can roll at a half chance check to determine if they notice or realize something that just jumps into their heads, this is a passive roll.
Roll vs Role Playing: How they do something is equally important as a dice roll. For example with trap finding: If a player tells me what they are going to do or how they are going to check, if it fits the scenario, I give them a bonus to the skill check roll. If a player tells me look for traps, without any detail or description, they just roll the dice. This is how a non-thief can potentially disarm a trap, or convince a stranger to do something, or anything else in game, etc.
Low Magic My world is an assumed low magic item world, every dweomered item essentially decays over months (or years), so going into a dungeon they might find info, scrolls and coins, but all the 'Real Magic' has long since faded back into the Ether. Only items found on an outer-plane or at last partially stuck in the Ether can avoid this, but then once on Nyssa, the decay starts to happen. There are ways to avoid this, but usually only available at higher levels.
Free Character Change No penalty for changing characters: outside of a dungeon. Go ahead, play what you want. Getting killed imposes a slight drop in level for starting a new character.
Dueling Proficiency: Most characters are proficient with both rapier and dagger, as duels are common and it is the weapon of choice for aristocrats and most soldiers. You can carry these anywhere. Many places allow dueling, as it's assumed that both parties consent. Even in places that do not allow dueling as a daily practice, it happens on Sword Day (last day of the Ten-Day week) as its a traditional fair day when competition happens. Duels, both for training and honor occur regularly. The majority of duels are stopped once three strikes happen or other stated condition.
Firearms are available in some remote locations much more common than urban ones. Though guns cannot be enchanted; ammunition can be. However, it is more common for ammunition to be made out of magical materials (like anthril), but is rare and expensive.
Spells or spell-like affects are not affected by critical or fumble rolls unless there are side rules specifically in the spell description.
Teleport Spell (5th level) can only be cast from one teleport pad to another. You must know the exact location of the second pad. If it is blocked (a simple cloth covering it) you cannot teleport through. It takes one hour to carve a temporary teleport insignia in sand (up to six hours if in stone.) The Greater Teleport (7th level) does not need a teleport pad to begin; but it always needs a teleport pad to go to.
A hoard of gold (especially coins) act as a blocker, which is one reasons why kings and dragons cannot be scryed. Top priority.
A hoard of silver (especially coins) acts as an enhancer to many spell & spell effects involving illusions. Most Fey collect silver for this reason. Seconded priority.
A hoard of platinum (especially coins) prevents charm spells & effects. Some say this is why it is so rare. No Priority - works when there are more platinum in one central location.
A hoard of electrum (especially coins) prevents deception in spells or spell effects.
A hoard of copper coins prevents strength draining magic or effects. Giants always have tonnes of copper in their lairs.